Formulation and Evaluation of Mucoadhesive Tablets Containing Eugenol for the Treatment of Periodontal Diseases

@article{Jadhav2004FormulationAE,
  title={Formulation and Evaluation of Mucoadhesive Tablets Containing Eugenol for the Treatment of Periodontal Diseases},
  author={Bhimrao K Jadhav and Kishanchandra Radheshyam Khandelwal and Anant R Ketkar and Sambhaji S. Pisal},
  journal={Drug Development and Industrial Pharmacy},
  year={2004},
  volume={30},
  pages={195 - 203}
}
Eugenol is the principle chemical constituent of clove oil and has been used to cure dental problems for ages. Eugenol is an integral part of the dentist's kit due to its analgesic, local anesthetic, anti‐;inflammatory, and antibacterial effects. It is used in the form of a paste or mixture as dental cement, filler, and restorative material. This study reports the development and evaluation of controlled‐release mucoadhesive tablets for gingival application, containing eugenol, which are… Expand
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References

SHOWING 1-10 OF 20 REFERENCES
Mucosal dosage form of lidocaine for toothache using hydroxypropyl cellulose and carbopol.
TLDR
A dosage form containing a local anesthetic for toothache was developed, using lidocaine as a model drug in HPC and CP as the peripheral base and the absorption when this dosage form was applied to the human gingiva was studied. Expand
Adhesive topical drug delivery system
TLDR
This may be the first case showing that insulin is able to be absorbed from oral mucosal membrane, and an adhesive tablet for aphthous stomatitis is developed and is now on the market. Expand
Effect in vitro of Tifell (formocresol-eugenol) on macrophage adhesion.
TLDR
Taking into account that substrate adherence is the first step in the phagocytic action of macrophages and in antigen presentation, Tifell could inhibit macrophage function and modulate immune and inflammatory responses in dental pulp and periapical tissues. Expand
The effect of the bleaching agent sodium perborate on macrophage adhesion in vitro: implications in external cervical root resorption.
TLDR
The inhibitory effect of sodium perborate on macrophage adhesion further supports the concept that this agent is not implicated in external cervical root resorption associated with intracoronal bleaching. Expand
Effects of formocresol alone vs. formocresol with eugenol on macrophage adhesion to plastic surfaces
Purpose: The purpose of this study was to compare the in-vitro effects of a European-based formocresol formulation that incorporates eugenol with formocresol alone on the adhesion of macrophages toExpand
Eugenol a valuable compound for in vitro experimental research and worthwhile for further in vivo investigation
Eugenol and isoeugenol are responsible for several pharmacological activities exhibited by nutmeg preparations. We studied their antimicrobial and antiaggregation activity in vitro and theirExpand
Effect of eugenol on macrophage adhesion in vitro to plastic surfaces.
TLDR
Taking into account that substrate adherence is the first step in the phagocytic process of macrophages and in antigen presentation, eugenol could inhibit macrophage function and modulate immune and inflammatory reactions in dental pulp and periapical tissues. Expand
Buccal mucosa as a route for systemic drug delivery: a review.
  • A. Shojaei
  • Medicine
  • Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 1998
TLDR
The structure and environment of the oral mucosa and the experimental methods used in assessing buccal drug permeation/absorption are discussed and bioadhesive polymeric based delivery systems are reviewed. Expand
The Selective Capsaicin Antagonist Capsazepine Abolishes the Antinociceptive Action of Eugenol and Guaiacol
TLDR
The results suggest that eugenol and guaiacol may exert their antinociceptive effects via the capsaicin receptor located on sensory terminals in the spinal cord. Expand
Analgesic efficacy and safety of an intraoral lidocaine patch.
TLDR
The authors conclude that the lidocaine patches used in this study are effective and safe in reducing needle insertion pain in adults. Expand
...
1
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...