• Corpus ID: 15179284

Formulation and Evaluation of Herbal Gel of Basella alba for wound healing activity

@inproceedings{Haneefa2012FormulationAE,
  title={Formulation and Evaluation of Herbal Gel of Basella alba for wound healing activity},
  author={Mohammed Haneefa and Anu Abraham and Saraswathi and Guru Prasad Mohanta and Chandini R. Nayar},
  year={2012}
}

• M. Haneefa, Anu Abraham, +2 authors Chandini R. Nayar
• Published 2012
• Medicine

Basella alba is used in many parts of the world for its medicinal use as laxative, anti-inflammatory, rubefacient, soothing as well as its cooling effects when applied to burns and scalds. It’s also used for haemorrhages, skin diseases, sexual weakness, ulcers and as laxative in children and pregnant women. In Nigeria, used for fertility enhancement in women, burn wounds etc. Hence the present study was chosen to evaluate its scientific validity. In the present study aqueous extract of leaves of Basella alba were formulated as a gel and investigated for its physicochemical as well as for its burn wound healing activity. Aqueous extract of dried leaves of Basella alba were subjected to preliminary phytochemical evaluation and wound healing activity studies. Different gel formulations of aqueous extract of Basella alba (2% w/v) were prepared using polymers carbopol 934 and carbopol 940 by varying their concentration. These formulations were evaluated for the following parameters: drug content, pH, viscosity, extrudability, spreadability, primary skin irritation, pharmacological activity and stability. Wound healing studies of aqueous extract revealed that Basella alba treated animals were found to epithelise in 23 days while the solvent control and untreated rats epithelise within 35days and 39 days respectively. The formulation 1.5% w/w carbopol 934 was found to be more promising as it shows better physicochemical characteristics, higher pharmacological activity and better stability compared to other formulations. So it was concluded that Basella alba aqueous extract shows significant improvement in burn wound contraction and hence this is a spromising candidate in burn wound healing.