Formulation and Evaluation of Gastroretentive Dosage Forms of Clarithromycin

  title={Formulation and Evaluation of Gastroretentive Dosage Forms of Clarithromycin},
  author={Muralidhar Nama and Chandra Sekhar Rao Gonugunta and Prabhakar reddy Veerareddy},
  journal={AAPS PharmSciTech},
The purpose of this research was to develop the hydrodynamically balanced delivery system of Clarithromycin (CLA) which, after oral administration should have the ability to prolong gastric residence time with the desired in vitro release profile for the localized action in the stomach, in the treatment of Helicobacter pylori (H.pylori) mediated peptic ulcer. By applying wet granulation technique floating tablets of Clarithromycin were prepared. The proportion of sodium bicarbonate was varied… CONTINUE READING