Formulation and Characterization of Polymeric Films Containing Combinations of Antiretrovirals (ARVs) for HIV Prevention

@article{Akil2014FormulationAC,
  title={Formulation and Characterization of Polymeric Films Containing Combinations of Antiretrovirals (ARVs) for HIV Prevention},
  author={Ayman Akil and Hrushikesh Bharat Agashe and Charlene S Dezzutti and Bernard J. Moncla and Sharon Louise Hillier and Br{\'i}d Devlin and Yuan Shi and Kevin Uranker and Lisa Cencia Rohan},
  journal={Pharmaceutical Research},
  year={2014},
  volume={32},
  pages={458-468}
}
To develop polymeric films containing dual combinations of anti-HIV drug candidate tenofovir, maraviroc and dapivirine for vaginal application as topical microbicides. A solvent casting method was used to manufacture the films. Solid phase solubility was used to identify potential polymers for use in the film formulation. Physical and chemical properties (such as water content, puncture strength and in vitro release) and product stability were determined. The bioactivity of the film products… CONTINUE READING
12 Citations
36 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Orally dissolving film strips (ODFS): the final evolution of orally dissolving dosage forms

  • M Hariharan, BA Bogue
  • Drug Deliv Technol
  • 2009
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…