Formulation Development of Sertraline Hydrochloride Microemulsion for Intranasal Delivery

  title={Formulation Development of Sertraline Hydrochloride Microemulsion for Intranasal Delivery},
  author={Amrish Kumar and Pankaj Sharma and Ashwani Chaturvedi and Durga Jaiswal and Meenakshi Bajpai and Mukesh Choudhary and Indranil Kumar Yadav and Hari Pratap Singh and Dinesh Chandra and Devendra Jain and Raj Kumar Goel},
Nasal cavity has used as alternative route for the drugs with poor water solubility, susceptible to acidic or enzymatic degradation and hepatic metabolism. The objective of the present study was to improve solubility of sertraline hydrochloride (STH), formulate microemulsions containing STH to accomplish rapid onset of action and to bypass the first-pass metabolism. A microemulsion system with Capmul MCM as oil phase, Labrasol as surfactant and Transcutol P as cosurfactant was developed for… CONTINUE READING


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