Formulation Development of Albendazole-Loaded Self-Microemulsifying Chewable Tablets to Enhance Dissolution and Bioavailability

@article{Sawatdee2019FormulationDO,
  title={Formulation Development of Albendazole-Loaded Self-Microemulsifying Chewable Tablets to Enhance Dissolution and Bioavailability},
  author={Somchai Sawatdee and Apichart Atipairin and Attawadee Sae Yoon and T. Srichana and N. Changsan and T. Suwandecha},
  journal={Pharmaceutics},
  year={2019},
  volume={11}
}
Albendazole is an anthelmintic agent with poor solubility and absorption. We developed a chewable tablet (200 mg drug equivalent), containing a self-microemulsifying drug delivery system (SMEDDS), with oral disintegrating properties. The emulsion was developed using sesame and soybean oils along with surfactant/co-surfactants, and the tablets were prepared by wet granulation using superdisintegrants and adsorbents. Infra-red (IR) spectral studies revealed no interaction between the drug and… Expand
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