Formulation Development of Albendazole-Loaded Self-Microemulsifying Chewable Tablets to Enhance Dissolution and Bioavailability

  title={Formulation Development of Albendazole-Loaded Self-Microemulsifying Chewable Tablets to Enhance Dissolution and Bioavailability},
  author={Somchai Sawatdee and Apichart Atipairin and Attawadee Sae Yoon and T. Srichana and N. Changsan and T. Suwandecha},
Albendazole is an anthelmintic agent with poor solubility and absorption. We developed a chewable tablet (200 mg drug equivalent), containing a self-microemulsifying drug delivery system (SMEDDS), with oral disintegrating properties. The emulsion was developed using sesame and soybean oils along with surfactant/co-surfactants, and the tablets were prepared by wet granulation using superdisintegrants and adsorbents. Infra-red (IR) spectral studies revealed no interaction between the drug and… Expand
Nanosuspension coated multiparticulates for controlled delivery of albendazole
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Preparation, Physicochemical Characterization and In Vitro and In Vivo Activity Against Heligmosomoides polygyrus of Novel Oral Formulations of Albendazole and Mebendazole
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The oral route is the most popular route for the clinical administration of drugs to treat various diseases. Before a drug is absorbed into the blood circulation, it must undergo dissolution andExpand
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Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer's Disease via Intranasal Administration
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  • Medicine
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  • 2021
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Formulation and characterization of albendazole chewable tablets
The objective of the present study was to develop an effective formulation of Albendazole chewable tablets.Albendazole (ABZ) is a benzimidazole derivative that has been widely used in the treatmentExpand
Formulation development of an albendazole self-emulsifying drug delivery system (SEDDS) with enhanced systemic exposure.
It was concluded that the SEDDS formulation approach can be used to improve the dissolution and systemic exposure of poorly water-soluble drugs such as ABZ. Expand
Development of Dispersible Self-microemulsifying Tablet of Atorvastatin
Aim: The aim of this study was to develop dispersible self-microemulsifying (SMEDDS) tablet of atorvastatin for promoting its solubility and thus its oral bioavailability. Materials and Methods: TheExpand
Solid self-microemulsifying dispersible tablets of celastrol: formulation development, charaterization and bioavailability evaluation.
The results suggest the potential use of SMEDDS dispersible tablets for the oral delivery of poorly water-soluble terpenes drugs, such as celastrol, according to the feasibility of the preparing process and redispersibility. Expand
Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS).
The results suggested that this solid SEDDS could be used as an effective oral solid dosage form to improve the bioavailability of poorly water-soluble drug dexibuprofen. Expand
Design and Evaluation of Self-Nanoemulsifying Drug Delivery System of Flutamide
The dissolution rate of FLT from SNEDDS was faster and higher in three different dissolution media such as 2% sodium lauryl sulfate, simulated gastric fluid, and simulated intestinal fluid. Expand
A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution
Abstract To enhance the dissolution of poorly soluble mefenamic acid, self-emulsifying formulation (SEF), composing of oil, surfactant and co-surfactant, was formulated. Among the oils andExpand
Oral Bioavailability and Lymphatic Transport of Pueraria Flavone-Loaded Self-Emulsifying Drug-Delivery Systems Containing Sodium Taurocholate in Rats
PFS-SMEDDSNR could significantly improve the oral relative absorption of PFs via the lymphatic uptake pathway, and SMEDDS containing NaTC may provide an effective approach for enhancing the oral bioavailability ofPFs. Expand
Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
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  • Chemistry, Medicine
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • 2004
Self-emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. Expand
Development of a solidified self-microemulsifying drug delivery system (S-SMEDDS) for atorvastatin calcium with improved dissolution and bioavailability.
The results suggest that S(M)-SEMDDS offers great potential for the development of solid dosage forms with improved oral absorption of drugs with poor water solubility. Expand