Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant.

@article{Matthews2008FormulationSA,
  title={Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant.},
  author={K. Matthews and H. Stevens and A. Auffret and M. J. Humphrey and G. Eccleston},
  journal={International journal of pharmaceutics},
  year={2008},
  volume={356 1-2},
  pages={
          110-20
        }
}
  • K. Matthews, H. Stevens, +2 authors G. Eccleston
  • Published 2008
  • Materials Science, Medicine
  • International journal of pharmaceutics
  • Lyophilised wafers are being developed as topical drug delivery systems for the treatment of chronic wounds. This study describes the formulation of xanthan wafers containing a selective, insoluble MMP-3 inhibitor (UK-370,106) and a non-ionic surfactant, designed to release accurate doses of UK-370,106 directly to a suppurating wound bed. Stability of UK-370,106 in the wafer compared to a non-lyophilised gel suspension was investigated using a combination of light scattering, thermal and… CONTINUE READING
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    References

    SHOWING 1-10 OF 33 REFERENCES
    Gamma-irradiation of lyophilised wound healing wafers.
    • 40
    Effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressings on dermal wound healing in diabetic mice
    • 145
    • PDF
    In vivo evaluation of nicotine lyophilised nasal insert in sheep.
    • 34