Formoxanthone C, isolated from Cratoxylum formosum ssp. pruniflorum, reverses anticancer drug resistance by inducing both apoptosis and autophagy in human A549 lung cancer cells.

@article{Kaewpiboon2018FormoxanthoneCI,
  title={Formoxanthone C, isolated from Cratoxylum formosum ssp. pruniflorum, reverses anticancer drug resistance by inducing both apoptosis and autophagy in human A549 lung cancer cells.},
  author={Chutima Kaewpiboon and N. Boonnak and S. Kaowinn and yOUNG-HWA cHUNG},
  journal={Bioorganic & medicinal chemistry letters},
  year={2018},
  volume={28 4},
  pages={
          820-825
        }
}
  • Chutima Kaewpiboon, N. Boonnak, +1 author yOUNG-HWA cHUNG
  • Published 2018
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • Multidrug resistance (MDR) cancer toward cancer chemotherapy is one of the obstacles in cancer therapy. Therefore, it is of interested to use formoxanthone C (1,3,5,6-tetraoxygenated xanthone; XanX), a natural compound, which showed cytotoxicity against MDR human A549 lung cancer (A549RT-eto). The treatment with XanX induced not only apoptosis- in A549RT-eto cells, but also autophagy-cell death. Inhibition of apoptosis did not block XanX-induced autophagy in A549RT-eto cells. Furthermore… CONTINUE READING
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    References

    SHOWING 1-10 OF 35 REFERENCES
    Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells
    • 78
    • PDF
    Synthesis and anti-cancer activities of new sulfonamides 4-substituted-triazolyl nucleosides.
    • 19
    The Role of Autophagy in Cancer: Therapeutic Implications
    • 912
    • PDF
    Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase.
    • 171
    • PDF
    Expression of a multidrug resistance gene in human cancers.
    • 1,147