Formoterol, a Long-Acting β2 Adrenergic Agonist, Improves Cognitive Function and Promotes Dendritic Complexity in a Mouse Model of Down Syndrome

@article{Dang2014FormoterolAL,
  title={Formoterol, a Long-Acting β2 Adrenergic Agonist, Improves Cognitive Function and Promotes Dendritic Complexity in a Mouse Model of Down Syndrome},
  author={Van Thac Dang and Brian Medina and D Sivananda Das and S Nazari Moghadam and Ahmad Salehi},
  journal={Biological Psychiatry},
  year={2014},
  volume={75},
  pages={179-188}
}
BACKGROUND Down syndrome is associated with significant failure in cognitive function. Our previous investigation revealed age-dependent degeneration of locus coeruleus, a major player in contextual learning, in the Ts65Dn mouse model of Down syndrome. We studied whether drugs already available for use in humans can be used to improve cognitive function in these mice. METHODS We studied the status of β adrenergic signaling in the dentate gyrus of the Ts65Dn mouse model of Down syndrome… CONTINUE READING
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