Formononetin promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells.

@article{Li2014FormononetinPC,
  title={Formononetin promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells.},
  author={Tianyu Li and Xinge Zhao and Zengnan Mo and Weihua Huang and Haibiao Yan and Zhian Ling and Yu Ye},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2014},
  volume={34 4},
  pages={1351-8}
}
BACKGROUND Formononetin is an O-methylated isoflavone isolated from the root of Astragalus membranaceus. It has already been reported that formononetin could inhibit cell proliferation and induce cell apoptosis in several cancers, including prostate cancer. This study aimed to further investigate whether cell cycle arrest is involved in formononetin… CONTINUE READING