Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse.

Abstract

T cell receptor (TCR)-mediated cytoskeletal reorganization is considered to be actin-related protein (Arp) 2/3 complex dependent. We therefore examined the requirement for Arp2/3- and formin-dependent F-actin nucleation during T cell activation. We demonstrated that without Arp2/3-mediated actin nucleation, stimulated T cells could not form an F-actin-rich… (More)

Topics

5 Figures and Tables

Cite this paper

@article{Gomez2007ForminsRT, title={Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse.}, author={Timothy S. Gomez and K. M. Kiran Kumar and Ricardo B. Medeiros and Yoji Shimizu and Paul J. Leibson and Daniel D Billadeau}, journal={Immunity}, year={2007}, volume={26 2}, pages={177-90} }