Forming the cell rear first: breaking cell symmetry to trigger directed cell migration


Directed cell migration requires the breaking of cell symmetry to generate a cell front and a cell rear along an axis approximately aligned with the direction of locomotion. In most cell types, regulated actin polymerization promotes initial cell front formation and its subsequent persistent protrusion, whereas myosin II-based forces are required to… (More)
DOI: 10.1038/ncb0710-628


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