Forming patterns in development without morphogen gradients: scattered differentiation and sorting out.

@article{Kay2009FormingPI,
  title={Forming patterns in development without morphogen gradients: scattered differentiation and sorting out.},
  author={Robert R Kay and Christopher R. L. Thompson},
  journal={Cold Spring Harbor perspectives in biology},
  year={2009},
  volume={1 6},
  pages={a001503}
}
Few mechanisms provide alternatives to morphogen gradients for producing spatial patterns of cells in development. One possibility is based on the sorting out of cells that initially differentiate in a salt and pepper mixture and then physically move to create coherent tissues. Here, we describe the evidence suggesting this is the major mode of patterning in Dictyostelium. In addition, we discuss whether convergent evolution could have produced a conceptually similar mechanism in other… CONTINUE READING

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