Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse

  title={Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse},
  author={Sricharan Murugesan and Jinsung Hong and Jason Yi and Dong Li and Jordan R Beach and Lin Shao and John Meinhardt and Grey Madison and Xufeng Wu and Eric Betzig and John A Hammer},
  booktitle={The Journal of cell biology},
Actin assembly and inward flow in the plane of the immunological synapse (IS) drives the centralization of T cell receptor microclusters (TCR MCs) and the integrin leukocyte functional antigen 1 (LFA-1). Using structured-illumination microscopy (SIM), we show that actin arcs populating the medial, lamella-like region of the IS arise from linear actin filaments generated by one or more formins present at the IS distal edge. After traversing the outer, Arp2/3-generated, lamellipodia-like region… CONTINUE READING
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