Formation of the vertebrate embryo: Moving beyond the Spemann organizer.

  title={Formation of the vertebrate embryo: Moving beyond the Spemann organizer.},
  author={Bernard V Thisse and Christine I Thisse},
  journal={Seminars in cell & developmental biology},
During the course of their classic experiments, Hilde Mangold and Hans Spemann discovered that the dorsal blastopore lip of an amphibian gastrula was able to induce formation of a complete embryonic axis when transplanted into the ventral side of a host gastrula embryo. Since then, the inducing activity of the dorsal lip has been known as the Spemann or dorsal organizer. During the past 25 years, studies performed in a variety of species have led to the identification of molecular factors… CONTINUE READING
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