Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3

@article{Pangburn1981FormationOT,
  title={Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3},
  author={Michael K. Pangburn and Robert D Schreiber and HANS J. MUELLER-EBERHARD},
  journal={The Journal of Experimental Medicine},
  year={1981},
  volume={154},
  pages={856 - 867}
}
Activation of the alternative pathway of complement commences with the formation of an initial fluid-phase C3 convertase. Treatment of C3 with the nucleophilic reagent methylamine has previously been shown to result in the cleavage of an intramolecular thioester bond and to induce C3b-like properties, including the ability to form a fluid-phase C3 convertase. This report examines the hypothesis that spontaneous hydrolysis of the thioester generates a derivative of C3 that is responsible for the… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Relation of a putative thioester bond in C3 to activation of the alternative pathway and the binding of C3b to biological targets of complement.,

  • M. K. Pangburn, H. J. Miiller-Eberhard
  • Exp. Med
  • 1980
Highly Influential
9 Excerpts

Similar Papers

Loading similar papers…