Formation of the NO donors glyceryl mononitrate and glyceryl mononitrite from the reaction of peroxynitrite with glycerol.

@article{White1997FormationOT,
  title={Formation of the NO donors glyceryl mononitrate and glyceryl mononitrite from the reaction of peroxynitrite with glycerol.},
  author={Charles R. White and Doug Moellering and Rakesh P Patel and Marion C. Kirk and Stephen Barnes and Victor M. Darley-Usmar},
  journal={The Biochemical journal},
  year={1997},
  volume={328 ( Pt 2)},
  pages={517-24}
}
Peroxynitrite (ONOO-), formed from the rapid reaction of superoxide (O2-.) with NO, is known to generate stable compounds capable of donating NO on reaction with thiols and molecules containing hydroxy groups. Using glycerol as a model compound for the reactions of ONOO- with biomolecules containing hydroxy groups, we separated the products and identified them by HPLC/MS. It was shown that both glyceryl mononitrate and glyceryl mononitrite were formed and released NO on incubation with copper… CONTINUE READING