Formation of the Long Range Dpp Morphogen Gradient

@inproceedings{Schwank2011FormationOT,
  title={Formation of the Long Range Dpp Morphogen Gradient},
  author={Gerald Schwank and Sascha Dalessi and Schu-Fee Yang and Ryohei Yagi and Aitana Morton de Lachapelle and Markus Affolter and Sven Bergmann and Konrad Basler},
  booktitle={PLoS biology},
  year={2011}
}
The TGF-β homolog Decapentaplegic (Dpp) acts as a secreted morphogen in the Drosophila wing disc, and spreads through the target tissue in order to form a long range concentration gradient. Despite extensive studies, the mechanism by which the Dpp gradient is formed remains controversial. Two opposing mechanisms have been proposed: receptor-mediated transcytosis (RMT) and restricted extracellular diffusion (RED). In these scenarios the receptor for Dpp plays different roles. In the RMT model it… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 66 references

Kinetics of morphogen gradient formation.

View 6 Excerpts
Highly Influenced

Do morphogen gradients arise by diffusion?

Developmental cell • 2002
View 6 Excerpts
Highly Influenced

Refined LexA transactivators and their use in combination with the Drosophila Gal4 system.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 2 Excerpts

Regulation of organ growth by morphogen gradients.

Cold Spring Harbor perspectives in biology • 2010
View 1 Excerpt

processes that project to the principal signaling center in Drosophila imaginal discs

TE Haerry
2010

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