Formation of the Long Range Dpp Morphogen Gradient

  title={Formation of the Long Range Dpp Morphogen Gradient},
  author={Gerald Schwank and Sascha Dalessi and Schu-Fee Yang and Ryohei Yagi and Aitana Morton de Lachapelle and Markus Affolter and Sven Bergmann and Konrad Basler},
  booktitle={PLoS biology},
The TGF-β homolog Decapentaplegic (Dpp) acts as a secreted morphogen in the Drosophila wing disc, and spreads through the target tissue in order to form a long range concentration gradient. Despite extensive studies, the mechanism by which the Dpp gradient is formed remains controversial. Two opposing mechanisms have been proposed: receptor-mediated transcytosis (RMT) and restricted extracellular diffusion (RED). In these scenarios the receptor for Dpp plays different roles. In the RMT model it… CONTINUE READING
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