Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb)

@article{Xu2006FormationOT,
  title={Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb)},
  author={Yan Xu and Hiroshi Sugiyama},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={949 - 954}
}
The formation of G-quadruplex and i-motif structures in the 5' end of the retinoblastoma (Rb) gene was examined using chemical modifications, circular dichroism (CD) and fluorescence spectroscopy. It was found that substitutions of 8-methylguanine at positions that show syn conformations in antiparallel G-quadruplexes stabilize the structure in the G-rich strand. The complementary C-rich 18mer forms an i-motif structure, as suggested by CD spectroscopy. Based on the C to T mutation experiments… CONTINUE READING

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