Formation of the Food Vacuole in Plasmodium falciparum: A Potential Role for the 19 kDa Fragment of Merozoite Surface Protein 1 (MSP119)

@article{Dluzewski2008FormationOT,
  title={Formation of the Food Vacuole in Plasmodium falciparum: A Potential Role for the 19 kDa Fragment of Merozoite Surface Protein 1 (MSP119)},
  author={Anton Richard Dluzewski and Irene T. Ling and John Mervyn Hopkins and Munira Grainger and G Margos and Graham Howard Mitchell and Anthony A. Holder and Lawrence Howard Bannister},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={379 - 382}
}
Plasmodium falciparum Merozoite Surface Protein 1 (MSP1) is synthesized during schizogony as a 195-kDa precursor that is processed into four fragments on the parasite surface. Following a second proteolytic cleavage during merozoite invasion of the red blood cell, most of the protein is shed from the surface except for the C-terminal 19-kDa fragment (MSP1(19)), which is still attached to the merozoite via its GPI-anchor. We have examined the fate of MSP1(19) during the parasite's subsequent… CONTINUE READING

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