Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma.

@article{Deng2012FormationOT,
  title={Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma.},
  author={Z. -M. Deng and Zhihua Wang and Chaomei Xiang and Aliah Molczan and Val{\'e}rie Baubet and Jos{\'e} Ram{\'o}n Conejo-Garcia and Xiaowei Xu and Paul M. Lieberman and Nadia Dahmane},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 18},
  pages={4383-94}
}
Telomeres play crucial roles in the maintenance of genome integrity and control of cellular senescence. Most eukaryotic telomeres can be transcribed to generate a telomeric repeat-containing RNA (TERRA) that persists as a heterogeneous nuclear RNA and can be developmentally regulated. However, the precise function and regulation of TERRA in normal and cancer cell development remains poorly understood. Here, we show that TERRA accumulates in highly proliferating normal and cancer cells, and… CONTINUE READING
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