Formation of strong airway irritants in mixtures of isoprene/ozone and isoprene/ozone/nitrogen dioxide.

@article{Wilkins2001FormationOS,
  title={Formation of strong airway irritants in mixtures of isoprene/ozone and isoprene/ozone/nitrogen dioxide.},
  author={Cornelius Kendall Wilkins and Per Axel Clausen and Peder Wolkoff and S\oren Thor Larsen and Maria Hammer and Kjeld Larsen and V. Kj{\ae}r Hansen and Gunnar Damg{\aa}rd Nielsen},
  journal={Environmental Health Perspectives},
  year={2001},
  volume={109},
  pages={937 - 941}
}
We evaluated the airway irritation of isoprene, isoprene/ozone, and isoprene/ozone/nitrogen dioxide mixtures using a mouse bioassay, from which we calculated sensory irritation, bronchial constriction, and pulmonary irritation. We observed significant sensory irritation (approximately 50% reduction of mean respiratory rate) by dynamically exposing the mice, over 30 min, to mixtures of isoprene and O3 or isoprene, O3, and NO2. The starting concentrations were approximately 4 ppm O3 and 500 ppm… CONTINUE READING
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