Formation of soluble immune complexes by complement in sera of patients with various hypocomplementemic states. Difference between inhibition of immune precipitation and solubilization.

@article{Schifferli1985FormationOS,
  title={Formation of soluble immune complexes by complement in sera of patients with various hypocomplementemic states. Difference between inhibition of immune precipitation and solubilization.},
  author={J{\"u}rg Alfred Schifferli and G H Steiger and Georges Hauptmann and Peter J. Sp{\"a}th and Anders G. Sj{\"o}holm},
  journal={The Journal of clinical investigation},
  year={1985},
  volume={76 6},
  pages={2127-33}
}
To examine whether the ability of complement to form soluble immune complexes plays a role in preventing immune complex-mediated diseases, we analyzed the capacity of complement to inhibit immune precipitation (IIP) and to solubilize preformed immune aggregates (SOL) in 23 sera of patients with various hypocomplementemic states, and we correlated the results of these studies with the clinical syndromes found in the various patients. In sera with deficiency or depletion of early classical… CONTINUE READING

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