Formation of secondary metabolism enzymes in the tylosin producerStreptomyces T59-235

Abstract

Production of the macrolide antibiotic tylosin byStreptomyces T59-235 was inhibited in cultures containing high phosphate concentrations (30 mM Pi). Vegetative growth (dry weight increase, DNA and RNA synthesis) was hardly affected. Tylosin production began when macromolecule synthesis had slowed down to minimum level; in cultures with 30 mM Pi the onset of… (More)
DOI: 10.1007/BF01054001

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