Formation of primary and secondary myotubes in aneural muscles in the mouse mutant peroneal muscular atrophy.

@article{Ashby1993FormationOP,
  title={Formation of primary and secondary myotubes in aneural muscles in the mouse mutant peroneal muscular atrophy.},
  author={Peter R. Ashby and Suzanne J Wilson and Andy J K Harris},
  journal={Developmental biology},
  year={1993},
  volume={156 2},
  pages={519-28}
}
The role of motor innervation in supporting and regulating muscle development was studied using aneural muscles in the hindlimb of the mouse mutant peroneal muscular atrophy (pma). This is a single-locus autosomal mutation where homozygous animals lack the common peroneal nerve, so that muscles in the anterolateral compartment of the lower leg develop entirely without innervation. In adults, these muscles are extremely atrophied, and the mice display a clubfoot deformity. The mutant animals… CONTINUE READING