Formation of physically stable amorphous phase of ibuprofen by solid state milling with kaolin.

@article{Mallick2008FormationOP,
  title={Formation of physically stable amorphous phase of ibuprofen by solid state milling with kaolin.},
  author={Subrata Mallick and Satyanarayan Pattnaik and Kalpana Swain and Pintu Kumar De and Arindam Saha and Gaurisankar Ghoshal and Arijit Mondal},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2008},
  volume={68 2},
  pages={346-51}
}
Ibuprofen was milled in the solid state with kaolin (hydrated aluminium silicate) in different ratio to examine the extent of transformation from crystalline to amorphous state. The physical stability of the resultant drug was also investigated. X-ray powder diffractometry (XRD) and birefringence by Scanning Electron Microscopy (SEM) studies indicated almost complete amorphization of the drug on ball milling with kaolin at 1:2 ratio. Fourier transform infrared spectroscopy (FTIR) data showed a… CONTINUE READING
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