Formation of native hepatitis C virus glycoprotein complexes.

  title={Formation of native hepatitis C virus glycoprotein complexes.},
  author={V Deleersnyder and Andr{\'e} Pillez and Czeslaw Wychowski and Keril Blight and Junjie Xu and Youn Soo Hahn and Charles M. Rice and Jean Dubuisson},
  journal={Journal of virology},
  volume={71 1},
The hepatitis C virus (HCV) glycoproteins (E1 and E2) interact to form a heterodimeric complex, which has been proposed as a functional subunit of the HCV virion envelope. As examined in cell culture transient-expression assays, the formation of properly folded, noncovalently associated E1E2 complexes is a slow and inefficient process. Due to lack of… CONTINUE READING