Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene

@article{Fendrick2007FormationOM,
  title={Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene},
  author={Sarah E Fendrick and Qing-Shan Xue and Wolfgang J Streit},
  journal={Journal of Neuroinflammation},
  year={2007},
  volume={4},
  pages={9 - 9}
}
BackgroundMicroglial neuroinflammation is thought to play a role in the pathogenesis of amyotrophic lateral sclerosis (ALS). The purpose of this study was to provide a histopathological evaluation of the microglial neuroinflammatory response in a rodent model of ALS, the SOD1G93A transgenic rat.MethodsMultiple levels of the CNS from spinal cord to cerebral cortex were studied in SOD1G93A transgenic rats during three stages of natural disease progression, including presymptomatic, early… CONTINUE READING

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