Formation of mineralized nodules by bone derived cells in vitro: a model of bone formation?

@article{Beresford1993FormationOM,
  title={Formation of mineralized nodules by bone derived cells in vitro: a model of bone formation?},
  author={Jon N. Beresford and Stephen E Graves and C A Smoothy},
  journal={American journal of medical genetics},
  year={1993},
  volume={45 2},
  pages={163-78}
}
The identification of the factors which regulate the proliferation and differentiation of cells of the osteoblast lineage remains one of the major challenges in the field of bone cell biology. Although considerable progress has been made in the isolation and culture of cells of the osteoblast lineage from both animal and, more recently, human bone, uncertainties have persisted as to the extent to which these cell populations retain the ability to differentiate into functional osteoblasts in… CONTINUE READING