Formation of methylated oxyarsenicals and thioarsenicals in wild-type and arsenic (+3 oxidation state) methyltransferase knockout mice exposed to arsenate.

@article{Naranmandura2013FormationOM,
  title={Formation of methylated oxyarsenicals and thioarsenicals in wild-type and arsenic (+3 oxidation state) methyltransferase knockout mice exposed to arsenate.},
  author={Hua Naranmandura and Kanwal Rehman and X Chris Le and David J Thomas},
  journal={Analytical and bioanalytical chemistry},
  year={2013},
  volume={405 6},
  pages={1885-91}
}
Arsenic (+3 oxidation state) methyltransferase (As3mt) plays a central role in the enzymatically catalyzed conversion of inorganic arsenic into methylated metabolites. Most studies of the metabolism and disposition of arsenicals following exposure to inorganic arsenic focus on the formation and fate of methylated oxyarsenicals. However, recent research has… CONTINUE READING