Formation of mammalian metabolites of cyclobenzaprine by the fungus, Cunninghamella elegans.

@article{Zhang1996FormationOM,
  title={Formation of mammalian metabolites of cyclobenzaprine by the fungus, Cunninghamella elegans.},
  author={D. Zhang and F. Evans and J. Freeman and Y. Yang and J. Deck and C. Cerniglia},
  journal={Chemico-biological interactions},
  year={1996},
  volume={102 2},
  pages={
          79-92
        }
}
  • D. Zhang, F. Evans, +3 authors C. Cerniglia
  • Published 1996
  • Biology, Medicine
  • Chemico-biological interactions
  • The fungus, Cunninghamella elegans, was used as a microbial model of mammalian drug metabolism to biotransform a tricyclic antidepressant, cyclobenzaprine. Seventy-five percent of this drug at a concentration of 1 mM was metabolized within 72 h by C. elegans grown on Sabouraud dextrose broth. Milligram amounts of fungal metabolites were isolated by reversed-phase high performance liquid chromatography (HPLC) and their structures were characterized by 1H NMR spectroscopy, mass spectrometry, and… CONTINUE READING
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    References

    SHOWING 1-10 OF 23 REFERENCES
    Biotransformation of amitriptyline by Cunninghamella elegans.
    • 47
    Microbial transformation of the antihistamine pyrilamine maleate. Formation of potential mammalian metabolites.
    • 33
    Metabolism of benz[a]anthracene by the filamentous fungus Cunninghamella elegans.
    • 31
    • PDF
    Metabolism of naphthalene by cell extracts of Cunninghamella elegans.
    • 63
    Physiological disposition and metabolism of cyclobenzaprine in the rat, dog, rhesus monkey, and man.
    • 46
    Microbial biotransformation of the angiotensin II antagonist GR117289 by Streptomyces rimosus to identify a mammalian metabolite.
    • 22
    Metabolism of cyclobenzaprine in the dog.
    • 6