• DOI:10.1016/S0009-2797(96)03736-2
Corpus ID: 2217046

Formation of mammalian metabolites of cyclobenzaprine by the fungus, Cunninghamella elegans.

@article{Zhang1996FormationOM,
  title={Formation of mammalian metabolites of cyclobenzaprine by the fungus, Cunninghamella elegans.},
  author={D. Zhang and F. Evans and J. Freeman and Y. Yang and J. Deck and C. Cerniglia},
  journal={Chemico-biological interactions},
  year={1996},
  volume={102 2},
  pages={
          79-92
        }
}

D. Zhang, F. Evans, +3 authors C. Cerniglia

Published 1996

Biology, Medicine

Chemico-biological interactions

The fungus, Cunninghamella elegans, was used as a microbial model of mammalian drug metabolism to biotransform a tricyclic antidepressant, cyclobenzaprine. Seventy-five percent of this drug at a concentration of 1 mM was metabolized within 72 h by C. elegans grown on Sabouraud dextrose broth. Milligram amounts of fungal metabolites were isolated by reversed-phase high performance liquid chromatography (HPLC) and their structures were characterized by 1H NMR spectroscopy, mass spectrometry, and… CONTINUE READING

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