Formation of mammalian metabolites of cyclobenzaprine by the fungus, Cunninghamella elegans.

  title={Formation of mammalian metabolites of cyclobenzaprine by the fungus, Cunninghamella elegans.},
  author={D. Zhang and F. Evans and J. Freeman and Y. Yang and J. Deck and C. Cerniglia},
  journal={Chemico-biological interactions},
  volume={102 2},
  • D. Zhang, F. Evans, +3 authors C. Cerniglia
  • Published 1996
  • Biology, Medicine
  • Chemico-biological interactions
  • The fungus, Cunninghamella elegans, was used as a microbial model of mammalian drug metabolism to biotransform a tricyclic antidepressant, cyclobenzaprine. Seventy-five percent of this drug at a concentration of 1 mM was metabolized within 72 h by C. elegans grown on Sabouraud dextrose broth. Milligram amounts of fungal metabolites were isolated by reversed-phase high performance liquid chromatography (HPLC) and their structures were characterized by 1H NMR spectroscopy, mass spectrometry, and… CONTINUE READING
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