Formation of layer-specific fiber projections to the hippocampus in vitro.

@article{Frotscher1993FormationOL,
  title={Formation of layer-specific fiber projections to the hippocampus in vitro.},
  author={Michael Frotscher and Bernd Heimrich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 21},
  pages={10400-3}
}
The factors determining the layer-specific termination of hippocampal afferents are not known. Previous studies have suggested that the laminated termination of afferent fiber systems is caused by their sequential ingrowth during development. Here we have tested this temporal hypothesis of fiber segregation by an in vitro confrontation system in which the sequential arrival of entorhinal and commissural fibers was reversed. However, despite the temporal reversal of ingrowth, both fiber systems… CONTINUE READING

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