Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells.

@article{Evanko1999FormationOH,
  title={Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells.},
  author={Stephen P. Evanko and John C. Angello and Thomas N Wight},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1999},
  volume={19 4},
  pages={1004-13}
}
The accumulation of hyaluronan (HA) and the HA-binding proteoglycan versican around smooth muscle cells in lesions of atherosclerosis suggests that together these molecules play an important role in the events of atherogenesis. In this study we have examined the formation of HA- and versican-rich pericellular matrices by human aortic smooth muscle cells in vitro, using a particle-exclusion assay, and the role of the pericellular matrix in cell proliferation and migration. The structural… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 61 references

Differences in the distribution of versican, decorin, and biglycan in atherosclerotic human coronary arteries.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology • 1997

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