Formation of human myocardium in the rat heart from human embryonic stem cells.

  title={Formation of human myocardium in the rat heart from human embryonic stem cells.},
  author={Michael A. Laflamme and Joseph Gold and Chunhui Xu and Mohammad Hassanipour and Elen S Rosler and S. M. Camengo Police and Veronica Muskheli and Charles E Murry},
  journal={The American journal of pathology},
  volume={167 3},
Human embryonic stem cells (hESCs) offer the opportunity to replenish cells lost in the postinfarct heart. We explored whether human myocardium could be generated in rat hearts by injecting differentiated cardiac-enriched hESC progeny into the left ventricular wall of athymic rats. Although initial grafts were predominantly epithelial, noncardiac elements were lost over time, and grafts consisted predominantly of cardiomyocytes by 4 weeks. No teratomatous elements were observed. Engrafted… CONTINUE READING


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