Formation of herpes simplex virus type 1 replication compartments by transfection: requirements and localization to nuclear domain 10.

@article{Lukonis1997FormationOH,
  title={Formation of herpes simplex virus type 1 replication compartments by transfection: requirements and localization to nuclear domain 10.},
  author={C J Lukonis and Sandra K Weller},
  journal={Journal of virology},
  year={1997},
  volume={71 3},
  pages={2390-9}
}
During infection, the seven essential herpes simplex virus type 1 (HSV-1) replication proteins are found in globular nuclear structures called replication compartments. Replication compartments form adjacent to ND10, nuclear matrix-bound domains which are present in most cell types but whose function is unknown (G. G. Maul, I. M. Ishov, and R. D. Everett, Virology 217:67-75, 1996). We now demonstrate that replication compartments can be formed by cotransfecting Vero cells with constructs… CONTINUE READING
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