Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment.

  title={Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment.},
  author={Tai-hsien Lee and Wei Yi and Michael D Griswold and Fengxue Zhu and Chengtao Her},
  journal={DNA repair},
  volume={5 1},
Increasing evidence suggests that components of the DNA mismatch repair (MMR) pathway play multifunctional roles beyond the scope of mismatch correction, including the modulation of cellular responses to DNA damage and homologous recombination. The heterocomplex consisting of MutS homologous proteins, hMSH4 and hMSH5, is believed to play essential roles in meiotic DNA repair particularly during the process of meiotic homologous recombination (HR). In order to gain a better understanding of the… CONTINUE READING
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