Formation of free hydroxyl radicals after pentylenetetrazol-induced seizure and kindling.

@article{Rauca1999FormationOF,
  title={Formation of free hydroxyl radicals after pentylenetetrazol-induced seizure and kindling.},
  author={Christine Rauca and Renate Zerbe and H Jantze},
  journal={Brain research},
  year={1999},
  volume={847 2},
  pages={347-51}
}
The present study indicates that free radicals have been implicated in pentylenetetrazol (PTZ)-induced seizure and kindling. In our experiments we used a method in which free hydroxyl radicals (* OH) are trapped by systemically applied salicylate in vivo, resulting in the stable and quantifiable products, 2, 3-dihydroxybenzoic acid (DHBA) and 2,5-DHBA. We investigated the formation of both 2,3- and 2,5-DHBA in the whole brain (without cerebellum) of rats treated with an acute seizure-inducing… CONTINUE READING
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