Formation of free choline in brain tissue during in vitro energy deprivation.

  title={Formation of free choline in brain tissue during in vitro energy deprivation.},
  author={Bogdan Djuricic and Sherry Olson and Hasan M Assaf and Tim S. Whittingham and W. David Lust and Lester R Drewes},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={11 2},
Free choline and ATP contents were measured in Mongolian gerbil hippocampal slices (tissue) and incubation media (media) during exposure to 30 min of aglycemia, high potassium, anoxia, or ischemia. Changes in choline levels reflected the degree of energy reduction, lower ATP levels being associated with high choline (4-fold increase during exposure to high potassium and anoxia, and 11-fold increase during ischemia). Media (extracellular) choline was particularly affected and increased about… CONTINUE READING
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