Formation of diethylstilbestrol-DNA adducts in human breast epithelial cells and inhibition by resveratrol.

@article{Hinrichs2011FormationOD,
  title={Formation of diethylstilbestrol-DNA adducts in human breast epithelial cells and inhibition by resveratrol.},
  author={Benjamin Hinrichs and Muhammad Zahid and Muhammad Mufazzal Saeed and Mohammed Fathy Adel Ali and Ercole L Cavalieri and Eleanor G. Rogan},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2011},
  volume={127 3-5},
  pages={276-81}
}
Extensive evidence exists that the reaction of estrogen metabolites with DNA produces depurinating adducts that, in turn, induce mutations and cellular transformation. While it is clear that these estrogen metabolites result in a neoplastic phenotype in vitro, further evidence supporting the link between estrogen-DNA adduct formation and its role in neoplasia induction in vivo would strengthen the evidence for a genotoxic mechanism. Diethylstilbestrol (DES), an estrogen analogue known to… CONTINUE READING