Formation of dendritic spines in cultured striatal neurons depends on excitatory afferent activity.

@article{Segal2003FormationOD,
  title={Formation of dendritic spines in cultured striatal neurons depends on excitatory afferent activity.},
  author={Menahem Segal and Varda Greenberger and Eduard Korkotian},
  journal={The European journal of neuroscience},
  year={2003},
  volume={17 12},
  pages={2573-85}
}
The role of afferent innervation in the formation of dendritic spines was studied in cultured rat striatum. The striatum is a unique structure in that it contains highly spiny GABAergic projection neurons, with no known local excitation. Grown alone in culture, striatal neurons did not express spontaneous network activity and were virtually devoid of dendritic spines. Adding GFP-expressing mouse cortical neurons to the striatal culture caused the appearance of spontaneous and evoked excitatory… CONTINUE READING

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