Formation of cystic ovarian follicles associated with elevated luteinizing hormone requires estrogen receptor-beta.

@article{Couse2004FormationOC,
  title={Formation of cystic ovarian follicles associated with elevated luteinizing hormone requires estrogen receptor-beta.},
  author={John Floyd Couse and Mariana M. Yates and Ryan B. Sanford and Abraham Nyska and John Helmer Nilson and Kenneth S. Korach},
  journal={Endocrinology},
  year={2004},
  volume={145 10},
  pages={
          4693-702
        }
}
Stringent regulation of LH secretion from the pituitary is vital to ovarian function in mammals. Two rodent models of LH hypersecretion are the transgenic LHbeta-C-terminal peptide (LHbetaCTP) and estrogen receptor-alpha (ERalpha)-null (alphaERKO) mice. Both exhibit ovarian phenotypes of chronic anovulation, cystic and hemorrhagic follicles, lack of corpora lutea, interstitial/stromal hyperplasia, and elevated plasma estradiol and testosterone. Because ERbeta is highly expressed in granulosa… CONTINUE READING
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