Formation of conjugates from ciprofloxacin and norfloxacin in cultures of Trichoderma viride

@article{Parshikov2002FormationOC,
  title={Formation of conjugates from ciprofloxacin and norfloxacin in cultures of Trichoderma viride},
  author={I. Parshikov and J. Moody and J. Freeman and J. O. Lay and Anna J. Williams and T. Heinze and J. Sutherland},
  journal={Mycologia},
  year={2002},
  volume={94},
  pages={1 - 5}
}
The formation of conjugates from two antibacterial fluoroquinolone drugs, ciprofloxacin and norfloxacin, was observed in cultures of Trichoderma viride that had been grown in sucrose-peptone broth and extracted 16 d after dosing with the drugs. Both conjugates were purified by high-performance liquid chromatography and found to be optically active. They were identified by mass and proton nuclear magnetic resonance spectra as 4-hydroxy-3-oxo-4-vinylcyclopent-1-enyl ciprofloxacin and 4-hydroxy-3… Expand
Microbial transformations of antimicrobial quinolones and related drugs
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