Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics.

Abstract

Nikkomycins, a group of peptidyl nucleoside antibiotics produced Streptomyces tendae Tü901, are potent competitive inhibitors of chitin synthase. In this study, three nikkomycin biosynthetic enzymes, NikP1, NikQ, and NikP2, were overexpressed, purified, and characterized. The NikP1 activated L-His and transferred it to the carrier protein domain to form L… (More)

Topics

Cite this paper

@article{Chen2002FormationOB, title={Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics.}, author={Huawei Chen and Brian K Hubbard and Sarah E O'Connor and Christopher T Walsh}, journal={Chemistry & biology}, year={2002}, volume={9 1}, pages={103-12} }