Formation of apolipoprotein AI-phosphatidylcholine core aldehyde Schiff base adducts promotes uptake by THP-1 macrophages.

@article{Ahmed2003FormationOA,
  title={Formation of apolipoprotein AI-phosphatidylcholine core aldehyde Schiff base adducts promotes uptake by THP-1 macrophages.},
  author={Zakaria Ahmed and Amir Ravandi and Graham F. Maguire and Arnis Kuksis and Philip W. Connelly},
  journal={Cardiovascular research},
  year={2003},
  volume={58 3},
  pages={712-20}
}
OBJECTIVE High-density lipoprotein (HDL) is believed to protect against development of atherosclerosis by inhibiting the accumulation of oxidized lipids in low-density lipoprotein (LDL). Paradoxically, HDL lipid is more susceptible to oxidation than LDL lipid. In the present study, we examined the effect of oxidized phospholipids on the uptake of HDL by macrophages. METHODS AND RESULTS Oxidation of HDL increased formation of phosphatidylcholine core aldehydes that was paralleled by increased… CONTINUE READING