Formation of angiotensin II and other angiotensin peptides from des-leu 10-angiotensin I in rat lung and kidney.

@article{Drummer1988FormationOA,
  title={Formation of angiotensin II and other angiotensin peptides from des-leu 10-angiotensin I in rat lung and kidney.},
  author={Olaf Heino Drummer and Stamatis Kourtis and H Johnson},
  journal={Biochemical pharmacology},
  year={1988},
  volume={37 22},
  pages={4327-33}
}
The formation of AII from a metabolite of AI, des-leu10-angiotensin I [A(1-9)] has been studied in centrifugal fractions of rat lung and kidney using gradient elution HPLC to monitor the formation of peptide products. AII-forming activity was present in kidney S2 (22.3 nmol/mg protein/min) but not in kidney P2 centrifugal fractions. Lung S2 fractions showed relatively weak AII-forming activity (0.34 nmole/mg protein/min) whilst no activity was observed in lung P2. Carboxypeptidase N-like… CONTINUE READING
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