Formation of an actin-like filament concurrent with the enzymatic synthesis of inorganic polyphosphate.

@article{GmezGarca2004FormationOA,
  title={Formation of an actin-like filament concurrent with the enzymatic synthesis of inorganic polyphosphate.},
  author={Mar{\'i}a del Roc{\'i}o G{\'o}mez-Garc{\'i}a and Arthur Kornberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 45},
  pages={15876-80}
}
Inorganic polyphosphate (poly P), a chain of hundreds of phosphate residues linked by ATP-like bonds, is found in every cell in nature and is commonly produced from ATP by poly P kinases (e.g., PPK1). Dictyostelium discoideum, the social slime mold, possesses a PPK activity (DdPPK1) with sequence similarity to bacterial PPKs. We find here a previously unrecognized PPK (DdPPK2) in D. discoideum with the sequences and properties of actin-related proteins (Arps) that are similar to muscle actins… CONTINUE READING

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