Formation of albumin dimers induced by exposure to peroxides in human plasma: a possible biomarker for oxidative stress.

@article{Ogasawara2006FormationOA,
  title={Formation of albumin dimers induced by exposure to peroxides in human plasma: a possible biomarker for oxidative stress.},
  author={Yuki Ogasawara and Tomoyuki Namai and Tadayasu Togawa and Kazuyuki Ishii},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={340 2},
  pages={353-8}
}
Human serum albumin (HSA) has one free thiol residue at Cys-34 that is likely oxidized by various reactive oxygen species (ROS). We attempted to identify the oxidation product of Cys-34 of HSA following exposure of plasma to ROS. Oxidation induced by tert-butyl hydroperoxide (t-BuOOH) of this free cysteine residue in HSA was observed in detail. Analysis of oxidized albumin in a partially purified fraction obtained by affinity column chromatography clearly revealed the formation of albumin… CONTINUE READING

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