Formation of acetaldehyde-derived DNA adducts due to alcohol exposure.

  title={Formation of acetaldehyde-derived DNA adducts due to alcohol exposure.},
  author={Hsu-Sheng Yu and Tsunehiro Oyama and Toyohi Isse and Kyoko Kitagawa and Thi-Thu-Phuong Pham and Masayuki Tanaka and Toshihiro Kawamoto},
  journal={Chemico-biological interactions},
  volume={188 3},
Epidemiological studies have identified chronic alcohol consumption as a significant risk factor for cancers of the upper aerodigestive tract, including the oral cavity, pharynx, larynx and esophagus, and for cancer of the liver. Ingested ethanol is mainly oxidized by the enzymes alcohol dehydrogenase (ADH), cytochrome P-450 2E1 (CYP2E1), and catalase to form acetaldehyde, which is subsequently oxidized by aldehyde dehydrogenase 2 (ALDH2) to produce acetate. Polymorphisms of the genes which… CONTINUE READING


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