Formation of aberrant phosphotau fibrillar polymers in neural cultured cells.

@article{Prez2002FormationOA,
  title={Formation of aberrant phosphotau fibrillar polymers in neural cultured cells.},
  author={Mar Mu{\~n}oz P{\'e}rez and F Navarro Hern{\'a}ndez and Alberto G{\'o}mez-Ramos and Mark Stevens Smith and George Sessions Perry and J{\'e}sus {\'A}vila},
  journal={European journal of biochemistry},
  year={2002},
  volume={269 5},
  pages={
          1484-9
        }
}
Here we show, for the first time, the in vitro formation of filamentous aggregates of phosphorylated tau protein in SH-SY5Y human neuroblastoma cells. The formation of such aberrant aggregates, similar to those occurring in vivo in Alzheimer's disease and other tauopathies, requires okadaic acid, a phosphatase inhibitor, to increase the level of phosphorylated tau, and hydroxynonenal, a product of oxidative stress that selectively adducts and modifies phosphorylated tau. Our findings suggest… CONTINUE READING
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Cellular models for tau filament assembly

  • Journal of Molecular Neuroscience
  • 2002
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