Formation of a nucleus pulposus-cartilage endplate construct in vitro.

  title={Formation of a nucleus pulposus-cartilage endplate construct in vitro.},
  author={Darla J Hamilton and Cheryle A. S{\'e}guin and Jian Wang and Robert M. Pilliar and Rita A Kandel},
  volume={27 3},
Intervertebral disc (IVD) degeneration is a common problem and treatment options for persistent symptomatic disease are limited. Tissue engineering is being explored for its ability to reconstitute the functional components of the IVD. The purpose of this study was to determine whether it was possible to form in vitro a triphasic construct consisting of nucleus pulposus (NP), cartilage endplate (CEP), and a porous calcium polyphosphate (CPP) bone substitute. Bovine articular chondrocytes were… CONTINUE READING


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